The sum is greater than the FGFR1 partner.
Cancer Cell
; 5(3): 203-4, 2004 Mar.
Article
in En
| MEDLINE
| ID: mdl-15050910
ABSTRACT
Cancer-associated chromosomal translocations create chimeric oncoproteins that contribute to aberrant growth by dominant or dominant negative mechanisms. Interestingly, genes such as MLL, RARA, and EWS are fused to multiple partners. This molecular promiscuity can provide important functional information, as specific translocations may be associated with discrete clinical and molecular features. In this issue of Cancer Cell, use a murine retroviral transduction/transplantation system to analyze two FGFR1 fusions found in hematologic malignancies. Their results show that these chromosomal rearrangements play a central role in pathogenesis, underscore the role of partner genes in modulating disease phenotypes, and uncover potential therapeutic targets.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Leukemia, Myeloid
/
Receptors, Fibroblast Growth Factor
/
Receptor Protein-Tyrosine Kinases
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Cancer Cell
Journal subject:
NEOPLASIAS
Year:
2004
Type:
Article