Structure-activity relationship of purine ribonucleosides for inhibition of hepatitis C virus RNA-dependent RNA polymerase.

Eldrup, Anne B; Allerson, Charles R; Bennett, C Frank; Bera, Sanjib; Bhat, Balkrishen; Bhat, Neelima; Bosserman, Michele R; Brooks, Jennifer; Burlein, Christine; Carroll, Steven S; Cook, P Dan; Getty, Krista L; MacCoss, Malcolm; McMasters, Daniel R; Olsen, David B; Prakash, Thazha P; Prhavc, Marija; Song, Quanlai; Tomassini, Joanne E; Xia, Jie

Eldrup, Anne B; Allerson, Charles R; Bennett, C Frank; Bera, Sanjib; Bhat, Balkrishen; Bhat, Neelima; Bosserman, Michele R; Brooks, Jennifer; Burlein, Christine; Carroll, Steven S; Cook, P Dan; Getty, Krista L; MacCoss, Malcolm; McMasters, Daniel R; Olsen, David B; Prakash, Thazha P; Prhavc, Marija; Song, Quanlai; Tomassini, Joanne E; Xia, Jie.

Affiliation

Eldrup AB; Department of Medicinal Chemistry, Isis Pharmaceuticals, 2280 Faraday Avenue, Carlsbad, California 92008, USA. aeldrup@isisph.com

J Med Chem ; 47(9): 2283-95, 2004 Apr 22.

Article in En | MEDLINE | ID: mdl-15084127

Subject(s)

Hepacivirus/chemistry; Purine Nucleosides/chemical synthesis; RNA-Dependent RNA Polymerase/antagonists & inhibitors; Ribonucleosides/chemical synthesis; Viral Nonstructural Proteins/antagonists & inhibitors; Adenosine Deaminase/chemistry; Hydrogen Bonding; Methylation; Molecular Conformation; Purine Nucleosides/chemistry; Purine-Nucleoside Phosphorylase/chemistry; Purines/chemistry; RNA-Dependent RNA Polymerase/chemistry; Ribonucleosides/chemistry; Ribose/chemistry; Structure-Activity Relationship; Viral Nonstructural Proteins/chemistry

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Collection: 01-internacional Database: MEDLINE Main subject: Purine Nucleosides / Ribonucleosides / RNA-Dependent RNA Polymerase / Viral Nonstructural Proteins / Hepacivirus Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2004 Type: Article Affiliation country: United States

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