N-acetylcysteine does not protect HepG2 cells against acetaminophen-induced apoptosis.

Manov, Irena; Hirsh, Mark; Iancu, Theodore C

Manov, Irena; Hirsh, Mark; Iancu, Theodore C.

Affiliation

Manov I; Pediatric Research and Electron Microscopy Unit, Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

Basic Clin Pharmacol Toxicol ; 94(5): 213-25, 2004 May.

Article in En | MEDLINE | ID: mdl-15125691

Subject(s)

Acetylcysteine/pharmacology; Antioxidants/pharmacology; Apoptosis; Cell Line, Tumor/drug effects; Acetaminophen/antagonists & inhibitors; Acetaminophen/toxicity; Apoptosis/drug effects; Calcium/analysis; Cations, Divalent; Cell Line, Tumor/metabolism; Cell Line, Tumor/ultrastructure; Cell Nucleus/drug effects; Cell Nucleus/ultrastructure; Flow Cytometry; Glutathione/analysis; Hepatoblastoma; Humans; Liver Neoplasms; Microscopy, Electron; Necrosis; Oxidation-Reduction; Oxidative Stress/drug effects; Phosphatidylserines/analysis

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Collection: 01-internacional Database: MEDLINE Main subject: Acetylcysteine / Apoptosis / Cell Line, Tumor / Antioxidants Limits: Humans Language: En Journal: Basic Clin Pharmacol Toxicol Journal subject: FARMACOLOGIA / TOXICOLOGIA Year: 2004 Type: Article Affiliation country: Israel

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