Modulation of deltaF508 cystic fibrosis transmembrane regulator trafficking and function with 4-phenylbutyrate and flavonoids.

Lim, Meerana; McKenzie, Karen; Floyd, Alexandra D; Kwon, Edwin; Zeitlin, Pamela L

Lim, Meerana; McKenzie, Karen; Floyd, Alexandra D; Kwon, Edwin; Zeitlin, Pamela L.

Affiliation

Lim M; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.

Am J Respir Cell Mol Biol ; 31(3): 351-7, 2004 Sep.

Article in En | MEDLINE | ID: mdl-15191910

Subject(s)

Chlorides/metabolism; Cystic Fibrosis Transmembrane Conductance Regulator/drug effects; Cystic Fibrosis/genetics; Flavonoids/pharmacology; Phenylbutyrates/pharmacology; Respiratory Mucosa/drug effects; Cystic Fibrosis Transmembrane Conductance Regulator/genetics; Cystic Fibrosis Transmembrane Conductance Regulator/metabolism; Dose-Response Relationship, Drug; Drug Therapy, Combination; Flavonoids/therapeutic use; Humans; Molecular Chaperones/drug effects; Molecular Chaperones/metabolism; Phenylbutyrates/therapeutic use; Protein Folding; Protein Transport/drug effects; Protein Transport/physiology; Respiratory Mucosa/metabolism; Respiratory Mucosa/physiopathology; Up-Regulation/drug effects; Up-Regulation/physiology

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Collection: 01-internacional Database: MEDLINE Main subject: Phenylbutyrates / Flavonoids / Chlorides / Cystic Fibrosis Transmembrane Conductance Regulator / Respiratory Mucosa / Cystic Fibrosis Limits: Humans Language: En Journal: Am J Respir Cell Mol Biol Journal subject: BIOLOGIA MOLECULAR Year: 2004 Type: Article Affiliation country: United States

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