The structure of MSK1 reveals a novel autoinhibitory conformation for a dual kinase protein.

Smith, Kathrine J; Carter, Paul S; Bridges, Angela; Horrocks, Pete; Lewis, Ceri; Pettman, Gary; Clarke, Andrew; Brown, Murray; Hughes, Jane; Wilkinson, Marc; Bax, Benjamin; Reith, Alastair

Smith, Kathrine J; Carter, Paul S; Bridges, Angela; Horrocks, Pete; Lewis, Ceri; Pettman, Gary; Clarke, Andrew; Brown, Murray; Hughes, Jane; Wilkinson, Marc; Bax, Benjamin; Reith, Alastair.

Affiliation

Smith KJ; Discovery Research, GlaxoSmithKline, Third Ave, Harlow, Essex, CM19 5AW, United Kingdom. katherine_j_smith@gsk.com

Structure ; 12(6): 1067-77, 2004 Jun.

Article in En | MEDLINE | ID: mdl-15274926

Subject(s)

Ribosomal Protein S6 Kinases, 90-kDa/chemistry; Adenosine Triphosphate/chemistry; Amino Acid Sequence; Animals; Binding Sites; Catalysis; Cell Line; Cloning, Molecular; Crystallography, X-Ray; Cyclic AMP-Dependent Protein Kinases/chemistry; Cyclic AMP-Dependent Protein Kinases/metabolism; Insecta; Mitogen-Activated Protein Kinase 1/metabolism; Mitogen-Activated Protein Kinases/metabolism; Models, Molecular; Molecular Sequence Data; Phosphorylation; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Sequence Homology, Amino Acid; p38 Mitogen-Activated Protein Kinases

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Collection: 01-internacional Database: MEDLINE Main subject: Ribosomal Protein S6 Kinases, 90-kDa Limits: Animals Language: En Journal: Structure Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA / BIOTECNOLOGIA Year: 2004 Type: Article Affiliation country: United kingdom

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