Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation.

Milano, Joseph; McKay, Jenny; Dagenais, Claude; Foster-Brown, Linda; Pognan, Francois; Gadient, Reto; Jacobs, Robert T; Zacco, Anna; Greenberg, Barry; Ciaccio, Paul J

Milano, Joseph; McKay, Jenny; Dagenais, Claude; Foster-Brown, Linda; Pognan, Francois; Gadient, Reto; Jacobs, Robert T; Zacco, Anna; Greenberg, Barry; Ciaccio, Paul J.

Affiliation

Milano J; Safety Assessment US, AstraZeneca Pharmaceuticals, 1800 Concord Pike, Wilmington, DE 19850, USA.

Toxicol Sci ; 82(1): 341-58, 2004 Nov.

Article in En | MEDLINE | ID: mdl-15319485

Subject(s)

Endopeptidases; Enzyme Inhibitors/pharmacology; Gene Expression Regulation/drug effects; Goblet Cells/metabolism; Receptors, Cell Surface/metabolism; Transcription Factors/metabolism; Amyloid Precursor Protein Secretases; Animals; Apoptosis/drug effects; Aspartic Acid Endopeptidases; Benzodiazepines/pharmacology; Biomarkers/analysis; Cell Differentiation/drug effects; Cell Line, Tumor; Dibenzazepines/pharmacology; Dose-Response Relationship, Drug; Endopeptidases/metabolism; Goblet Cells/pathology; Humans; Male; Metaplasia; RNA, Messenger/analysis; Rats; Rats, Wistar; Receptor, Notch1; Receptors, Cell Surface/genetics; Signal Transduction; Sulfonamides/pharmacology; Transcription Factors/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: Endopeptidases / Transcription Factors / Gene Expression Regulation / Receptors, Cell Surface / Goblet Cells / Enzyme Inhibitors Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Toxicol Sci Journal subject: TOXICOLOGIA Year: 2004 Type: Article Affiliation country: United States

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