A single treatment of yttrium-90-labeled CHX-A"-C6.5 diabody inhibits the growth of established human tumor xenografts in immunodeficient mice.

Adams, Gregory P; Shaller, Calvin C; Dadachova, Ekaterina; Simmons, Heidi H; Horak, Eva M; Tesfaye, Abohawariat; Klein-Szanto, Andres J P; Marks, James D; Brechbiel, Martin W; Weiner, Louis M

Adams, Gregory P; Shaller, Calvin C; Dadachova, Ekaterina; Simmons, Heidi H; Horak, Eva M; Tesfaye, Abohawariat; Klein-Szanto, Andres J P; Marks, James D; Brechbiel, Martin W; Weiner, Louis M.

Affiliation

Adams GP; Divison of Medical Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA. gp_adams@fccc.edu

Cancer Res ; 64(17): 6200-6, 2004 Sep 01.

Article in En | MEDLINE | ID: mdl-15342405

Subject(s)

Breast Neoplasms/radiotherapy; Immunotoxins/pharmacology; Isothiocyanates/pharmacology; Ovarian Neoplasms/radiotherapy; Pentetic Acid/analogs & derivatives; Pentetic Acid/pharmacology; Yttrium Radioisotopes/pharmacology; Animals; Breast Neoplasms/diagnostic imaging; Breast Neoplasms/immunology; Breast Neoplasms/metabolism; Cell Line, Tumor; Female; Humans; Immunoglobulin Variable Region/administration & dosage; Immunoglobulin Variable Region/metabolism; Immunoglobulin Variable Region/pharmacology; Immunotoxins/pharmacokinetics; Isothiocyanates/administration & dosage; Isothiocyanates/pharmacokinetics; Mice; Mice, Nude; Mice, SCID; Ovarian Neoplasms/diagnostic imaging; Ovarian Neoplasms/immunology; Ovarian Neoplasms/metabolism; Pentetic Acid/administration & dosage; Pentetic Acid/pharmacokinetics; Radioimmunotherapy; Radionuclide Imaging; Receptor, ErbB-2/biosynthesis; Tissue Distribution; Xenograft Model Antitumor Assays; Yttrium Radioisotopes/administration & dosage; Yttrium Radioisotopes/pharmacokinetics

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Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Yttrium Radioisotopes / Breast Neoplasms / Immunotoxins / Isothiocyanates / Pentetic Acid Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Cancer Res Year: 2004 Type: Article Affiliation country: United States

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