Cardiac specific increase in aldosterone production induces coronary dysfunction in aldosterone synthase-transgenic mice.

Garnier, Anne; Bendall, Jennifer K; Fuchs, Sebastien; Escoubet, Brigitte; Rochais, Francesca; Hoerter, Jacqueline; Nehme, Johnny; Ambroisine, Marie-Lory; De Angelis, Noeleen; Morineau, Gilles; d'Estienne, Pauline; Fischmeister, Rodolphe; Heymes, Christophe; Pinet, Florence; Delcayre, Claude

Garnier, Anne; Bendall, Jennifer K; Fuchs, Sebastien; Escoubet, Brigitte; Rochais, Francesca; Hoerter, Jacqueline; Nehme, Johnny; Ambroisine, Marie-Lory; De Angelis, Noeleen; Morineau, Gilles; d'Estienne, Pauline; Fischmeister, Rodolphe; Heymes, Christophe; Pinet, Florence; Delcayre, Claude.

Affiliation

Garnier A; INSERM U572, Université Paris 7, France.

Circulation ; 110(13): 1819-25, 2004 Sep 28.

Article in En | MEDLINE | ID: mdl-15364804

Subject(s)

Aldosterone/biosynthesis; Coronary Vessels/pathology; Cytochrome P-450 CYP11B2/physiology; Endothelium, Vascular/pathology; Myocardium/metabolism; Acetylcholine/pharmacology; Animals; Bradykinin/pharmacology; Calcium/metabolism; Collagen/biosynthesis; Coronary Circulation; Coronary Vessels/metabolism; Cytochrome P-450 CYP11B2/genetics; Endothelium, Vascular/metabolism; Ion Channels/metabolism; Ion Transport; Male; Mice; Mice, Transgenic; Nitric Oxide/biosynthesis; Nitroprusside/pharmacology; Organ Specificity; Patch-Clamp Techniques; Potassium/metabolism; RNA, Messenger/biosynthesis; Rats; Receptors, Angiotensin/biosynthesis; Recombinant Fusion Proteins/biosynthesis; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/physiology; Transgenes; Vasodilation/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Endothelium, Vascular / Cytochrome P-450 CYP11B2 / Coronary Vessels / Aldosterone / Myocardium Type of study: Prognostic_studies Limits: Animals Language: En Journal: Circulation Year: 2004 Type: Article Affiliation country: France

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