Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension.

Bátkai, Sándor; Pacher, Pál; Osei-Hyiaman, Douglas; Radaeva, Svetlana; Liu, Jie; Harvey-White, Judith; Offertáler, László; Mackie, Ken; Rudd, M Audrey; Bukoski, Richard D; Kunos, George

Bátkai, Sándor; Pacher, Pál; Osei-Hyiaman, Douglas; Radaeva, Svetlana; Liu, Jie; Harvey-White, Judith; Offertáler, László; Mackie, Ken; Rudd, M Audrey; Bukoski, Richard D; Kunos, George.

Affiliation

Bátkai S; Laboratory of Physiologic Studies, National Institute on Alcohol Abuse & Alcoholism, National Institutes of Health, Bethesda, Md 20892-8115, USA.

Circulation ; 110(14): 1996-2002, 2004 Oct 05.

Article in En | MEDLINE | ID: mdl-15451779

Subject(s)

Arachidonic Acids/pharmacology; Blood Pressure/drug effects; Dronabinol/analogs & derivatives; Hypertension/physiopathology; Myocardial Contraction/drug effects; Receptor, Cannabinoid, CB1/drug effects; Vascular Resistance/drug effects; Amidohydrolases/antagonists & inhibitors; Angiotensin II/toxicity; Animals; Arachidonic Acids/metabolism; Benzamides/pharmacology; Benzyl Compounds/pharmacology; Blood Pressure/physiology; Camphanes/pharmacology; Carbamates/pharmacology; Dronabinol/pharmacology; Endocannabinoids; Endothelium, Vascular/metabolism; Hypertension/chemically induced; Hypertension/genetics; Male; Models, Cardiovascular; Myocardial Contraction/physiology; Myocardium/metabolism; Piperidines/pharmacology; Polyunsaturated Alkamides; Pyrazoles/pharmacology; Rats; Rats, Inbred Dahl; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1/physiology; Rimonabant; Up-Regulation; Vascular Resistance/physiology; Vasodilation/drug effects; Vasodilation/physiology; Ventricular Function, Left/drug effects; Ventricular Function, Left/physiology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dronabinol / Vascular Resistance / Blood Pressure / Arachidonic Acids / Receptor, Cannabinoid, CB1 / Hypertension / Myocardial Contraction Language: En Journal: Circulation Year: 2004 Type: Article Affiliation country: United States

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