The codon 620 tryptophan allele of the lymphoid tyrosine phosphatase (LYP) gene is a major determinant of Graves' disease.

Velaga, M R; Wilson, V; Jennings, C E; Owen, C J; Herington, S; Donaldson, P T; Ball, S G; James, R A; Quinton, R; Perros, P; Pearce, S H S

Velaga, M R; Wilson, V; Jennings, C E; Owen, C J; Herington, S; Donaldson, P T; Ball, S G; James, R A; Quinton, R; Perros, P; Pearce, S H S.

Affiliation

Velaga MR; Institute of Human Genetics, University of Newcastle upon Tyne NE1 3BZ, United Kingdom.

J Clin Endocrinol Metab ; 89(11): 5862-5, 2004 Nov.

Article in En | MEDLINE | ID: mdl-15531553

Subject(s)

Alleles; Codon; Graves Disease/genetics; Lymphocytes/enzymology; Polymorphism, Single Nucleotide; Protein Tyrosine Phosphatases/genetics; Addison Disease/genetics; Humans; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Tryptophan/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: Codon / Lymphocytes / Graves Disease / Protein Tyrosine Phosphatases / Polymorphism, Single Nucleotide / Alleles Limits: Humans Language: En Journal: J Clin Endocrinol Metab Year: 2004 Type: Article Affiliation country: United kingdom

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