Beta-cell-targeted expression of a dominant-negative mutant of hepatocyte nuclear factor-1alpha in mice: diabetes model with beta-cell dysfunction partially rescued by nonglucose secretagogues.

Winzell, Maria Sörhede; Pacini, Giovanni; Wollheim, Claes B; Ahrén, Bo

Winzell, Maria Sörhede; Pacini, Giovanni; Wollheim, Claes B; Ahrén, Bo.

Affiliation

Winzell MS; Department of Medicine, Lund University, B11 BMC, SE-221 84 Lund, Sweden.

Diabetes ; 53 Suppl 3: S92-6, 2004 Dec.

Article in En | MEDLINE | ID: mdl-15561929

Subject(s)

DNA-Binding Proteins/genetics; Islets of Langerhans/physiology; Nuclear Proteins/genetics; Transcription Factors/genetics; Animals; Arginine/pharmacology; Blood Glucose/metabolism; Carbachol/pharmacology; Genes, Dominant; Glucose/pharmacology; Hepatocyte Nuclear Factor 1; Hepatocyte Nuclear Factor 1-alpha; Insulin/analysis; Insulin/metabolism; Insulin Secretion; Islets of Langerhans/drug effects; Islets of Langerhans/metabolism; Male; Mice; Mice, Transgenic; Mutation; Palmitic Acid/pharmacology; Potassium Chloride/pharmacology; Rats

Search on Google

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Nuclear Proteins / Islets of Langerhans / DNA-Binding Proteins Type of study: Prognostic_studies Limits: Animals Language: En Journal: Diabetes Year: 2004 Type: Article Affiliation country: Sweden

Search on Google

XML

PubMed Links