The cytoskeleton and mRNA localization.

Singer, R H

Singer, R H.

Affiliation

Singer RH; Department of Cell Biology, University of Massachusetts, Worcester 01655.

Curr Opin Cell Biol ; 4(1): 15-9, 1992 Feb.

Article in En | MEDLINE | ID: mdl-1558749

ABSTRACT

ABSTRACT

The localization of mRNA appears to facilitate protein sorting, so that proteins are synthesized in specific cellular regions. The spatial information on the mRNA may be transduced by proteins that recognize specific localizing sequences on the 3' end and then chaperone the mRNA, presumably along filaments, to its destination. Additional sequences such as poly(A), or the nascent chains of cytoskeleton-associated proteins, may then anchor mRNAs on the cytoskeleton.

Subject(s)

Cytoskeletal Proteins/metabolism; Cytoskeleton/metabolism; RNA, Messenger/metabolism; Animals; Biological Transport, Active; Cytoplasm/metabolism; Gene Expression; Protein Processing, Post-Translational

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PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Cytoskeleton / RNA, Messenger / Cytoskeletal Proteins Limits: Animals Language: En Journal: Curr Opin Cell Biol Year: 1992 Type: Article

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