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Dual angiotensin II and endothelin A receptor antagonists: synthesis of 2'-substituted N-3-isoxazolyl biphenylsulfonamides with improved potency and pharmacokinetics.
Murugesan, Natesan; Gu, Zhengxiang; Fadnis, Leena; Tellew, John E; Baska, Rose Ann F; Yang, Yifan; Beyer, Sophie M; Monshizadegan, Hossain; Dickinson, Kenneth E; Valentine, Maria T; Humphreys, W Griffith; Lan, Shih-Jung; Ewing, William R; Carlson, Kenneth E; Kowala, Mark C; Zahler, Robert; Macor, John E.
Affiliation
  • Murugesan N; Discovery Chemistry and Metabolic and Cardiovascular Drug Discovery, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543-5400 USA. natesan.murugesan@bms.com
J Med Chem ; 48(1): 171-9, 2005 Jan 13.
Article in En | MEDLINE | ID: mdl-15634011
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Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Receptor, Angiotensin, Type 1 / Angiotensin II Type 1 Receptor Blockers / Endothelin A Receptor Antagonists / Isoxazoles Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2005 Type: Article
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PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Receptor, Angiotensin, Type 1 / Angiotensin II Type 1 Receptor Blockers / Endothelin A Receptor Antagonists / Isoxazoles Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2005 Type: Article