S100B protein levels in saliva: correlation with gestational age in normal term and preterm newborns.
Clin Biochem
; 38(3): 229-33, 2005 Mar.
Article
in En
| MEDLINE
| ID: mdl-15708543
ABSTRACT
OBJECTIVES:
S100B is an acidic calcium-binding protein of the EF-hand family present in the central nervous system, where it is concentrated in glial cells. It has been suggested to act as a cytokine with neurotrophic effects at physiological concentrations. DESIGN ANDMETHODS:
S100B concentration was assessed in saliva by western blot analysis and an immunoluminometric assay. A reference curve of the protein was established in 216 preterm and term newborns.RESULTS:
S100B levels were significantly higher in saliva taken from the preterm group, and the highest S100B levels were found in newborns who were delivered in the earlier weeks of gestation, exhibiting a progressive decrease nearer to term. S100B concentration in saliva was correlated with gestational age (r = -0.69; P < 0.001).CONCLUSIONS:
The present study offers data consistent with the putative neurotrophic role of S100B and suggests the usefulness of saliva in the clinical monitoring of S100B levels.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Saliva
/
Infant, Newborn
/
Infant, Premature
/
Biomarkers
/
S100 Proteins
/
Gestational Age
Type of study:
Evaluation_studies
Limits:
Female
/
Humans
/
Male
Language:
En
Journal:
Clin Biochem
Year:
2005
Type:
Article
Affiliation country:
Italy