Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.

Johnson, Steven M; Petrassi, H Michael; Palaninathan, Satheesh K; Mohamedmohaideen, Nilofar N; Purkey, Hans E; Nichols, Christopher; Chiang, Kyle P; Walkup, Traci; Sacchettini, James C; Sharpless, K Barry; Kelly, Jeffery W

Johnson, Steven M; Petrassi, H Michael; Palaninathan, Satheesh K; Mohamedmohaideen, Nilofar N; Purkey, Hans E; Nichols, Christopher; Chiang, Kyle P; Walkup, Traci; Sacchettini, James C; Sharpless, K Barry; Kelly, Jeffery W.

Affiliation

Johnson SM; Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA.

J Med Chem ; 48(5): 1576-87, 2005 Mar 10.

Article in En | MEDLINE | ID: mdl-15743199

Subject(s)

Amyloid/antagonists & inhibitors; Ethers/chemical synthesis; Hydrazines/chemical synthesis; Oximes/chemical synthesis; Prealbumin/antagonists & inhibitors; Amyloid/metabolism; Crystallography, X-Ray; Drug Stability; Ethers/blood; Ethers/chemistry; Humans; Hydrazines/blood; Hydrazines/chemistry; In Vitro Techniques; Oximes/blood; Oximes/chemistry; Prealbumin/metabolism; Protein Binding; Protein Structure, Quaternary; Structure-Activity Relationship; Ultracentrifugation

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Collection: 01-internacional Database: MEDLINE Main subject: Oximes / Prealbumin / Ethers / Amyloid / Hydrazines Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2005 Type: Article Affiliation country: United States

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