Phase I study of MetXia-P450 gene therapy and oral cyclophosphamide for patients with advanced breast cancer or melanoma.

Braybrooke, Jeremy P; Slade, Andrew; Deplanque, Gael; Harrop, Richard; Madhusudan, Srinivasan; Forster, Martin D; Gibson, Rachel; Makris, Andreas; Talbot, Denis C; Steiner, Jan; White, Linda; Kan, On; Naylor, Stuart; Carroll, Miles W; Kingsman, Sue M; Harris, Adrian L

Braybrooke, Jeremy P; Slade, Andrew; Deplanque, Gael; Harrop, Richard; Madhusudan, Srinivasan; Forster, Martin D; Gibson, Rachel; Makris, Andreas; Talbot, Denis C; Steiner, Jan; White, Linda; Kan, On; Naylor, Stuart; Carroll, Miles W; Kingsman, Sue M; Harris, Adrian L.

Affiliation

Braybrooke JP; Cancer Research UK Medical Oncology Unit, Churchill Hospital, Oxford OX3 7LJ, UK.

Clin Cancer Res ; 11(4): 1512-20, 2005 Feb 15.

Article in En | MEDLINE | ID: mdl-15746054

Subject(s)

Aryl Hydrocarbon Hydroxylases/metabolism; Breast Neoplasms/therapy; Cyclophosphamide/therapeutic use; Genetic Therapy/methods; Melanoma/therapy; Oxidoreductases, N-Demethylating/metabolism; Administration, Oral; Adult; Aged; Antineoplastic Agents, Alkylating/administration & dosage; Antineoplastic Agents, Alkylating/metabolism; Antineoplastic Agents, Alkylating/therapeutic use; Aryl Hydrocarbon Hydroxylases/genetics; Breast Neoplasms/genetics; Breast Neoplasms/immunology; Carcinoembryonic Antigen/analysis; Cell Line, Tumor; Cyclophosphamide/administration & dosage; Cyclophosphamide/metabolism; Cytochrome P-450 CYP2B6; Enzyme-Linked Immunosorbent Assay; Female; Genetic Vectors/administration & dosage; Genetic Vectors/genetics; Humans; Immunohistochemistry; Male; Melanoma/genetics; Melanoma/immunology; Middle Aged; Mucin-1/analysis; Oxidoreductases, N-Demethylating/genetics; Time Factors; Treatment Outcome

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Collection: 01-internacional Database: MEDLINE Main subject: Oxidoreductases, N-Demethylating / Breast Neoplasms / Aryl Hydrocarbon Hydroxylases / Genetic Therapy / Cyclophosphamide / Melanoma Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2005 Type: Article Affiliation country: United kingdom

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