Expression, pharmacological profile, and functional coupling of A2B receptors in a recombinant system and in peripheral blood cells using a novel selective antagonist radioligand, [3H]MRE 2029-F20.

Gessi, Stefania; Varani, Katia; Merighi, Stefania; Cattabriga, Elena; Pancaldi, Cecilia; Szabadkai, Youri; Rizzuto, Rosario; Klotz, Karl-Norbert; Leung, Edward; Mac Lennan, Stephen; Baraldi, Pier Giovanni; Borea, Pier Andrea

Gessi, Stefania; Varani, Katia; Merighi, Stefania; Cattabriga, Elena; Pancaldi, Cecilia; Szabadkai, Youri; Rizzuto, Rosario; Klotz, Karl-Norbert; Leung, Edward; Mac Lennan, Stephen; Baraldi, Pier Giovanni; Borea, Pier Andrea.

Affiliation

Gessi S; Faculty of Medicine, Department of Clinical and Experimental Medicine, Pharmacology Unit, University of Ferrara, Via Fossato di Mortara 17-19, 44100 Ferrara, Italy.

Mol Pharmacol ; 67(6): 2137-47, 2005 Jun.

Article in En | MEDLINE | ID: mdl-15788741

Subject(s)

Acetamides/pharmacology; Adenosine A2 Receptor Antagonists; Leukocytes, Mononuclear/drug effects; Purines/pharmacology; Pyrazoles/pharmacology; Receptor, Adenosine A2B/biosynthesis; Adenosine-5'-(N-ethylcarboxamide)/pharmacology; Cell Line; Dose-Response Relationship, Drug; Gene Expression Regulation/drug effects; Gene Expression Regulation/physiology; Humans; Leukocytes, Mononuclear/metabolism; Protein Binding/drug effects; Protein Binding/physiology; Receptor, Adenosine A2B/genetics; Recombinant Proteins/antagonists & inhibitors; Recombinant Proteins/biosynthesis; Recombinant Proteins/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: Purines / Pyrazoles / Leukocytes, Mononuclear / Receptor, Adenosine A2B / Adenosine A2 Receptor Antagonists / Acetamides Limits: Humans Language: En Journal: Mol Pharmacol Year: 2005 Type: Article Affiliation country: Italy

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