Complement-regulatory proteins in severe malaria: too little or too much of a good thing?
Trends Parasitol
; 21(5): 218-23, 2005 May.
Article
in En
| MEDLINE
| ID: mdl-15837610
ABSTRACT
Data from several laboratories suggest that erythrocyte complement-regulatory proteins, in particular complement receptor 1 (CR1), are important in the pathogenesis of severe malaria. Additional studies suggest that the levels of expression of CR1 and the complement regulator CD55 on erythrocytes vary with age, being low in young children and increasing with age. It is proposed that the interplay between the rate at which immunity develops during malaria exposure and the changes in levels of erythrocyte complement-regulatory proteins that occur with age might contribute to the differences in epidemiology of severe malaria-associated anaemia and cerebral malaria.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Aging
/
Receptors, Complement
/
CD55 Antigens
/
Malaria
Type of study:
Etiology_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Trends Parasitol
Journal subject:
PARASITOLOGIA
Year:
2005
Type:
Article
Affiliation country:
United States