An anti-CD45RO/RB monoclonal antibody modulates T cell responses via induction of apoptosis and generation of regulatory T cells.

Gregori, Silvia; Mangia, Patrizia; Bacchetta, Rosa; Tresoldi, Eleonora; Kolbinger, Frank; Traversari, Catia; Carballido, Josè M; de Vries, Jan E; Korthäuer, Ulf; Roncarolo, Maria-Grazia

Gregori, Silvia; Mangia, Patrizia; Bacchetta, Rosa; Tresoldi, Eleonora; Kolbinger, Frank; Traversari, Catia; Carballido, Josè M; de Vries, Jan E; Korthäuer, Ulf; Roncarolo, Maria-Grazia.

Affiliation

Gregori S; San Raffaele Telethon Institute for Gene Therapy, 20132 Milan, Italy.

J Exp Med ; 201(8): 1293-305, 2005 Apr 18.

Article in En | MEDLINE | ID: mdl-15837814

Subject(s)

Antibodies, Monoclonal/pharmacology; CD4-Positive T-Lymphocytes/drug effects; CD8-Positive T-Lymphocytes/drug effects; Leukocyte Common Antigens/immunology; Animals; Apoptosis; CD3 Complex; CD4-Positive T-Lymphocytes/immunology; CD8-Positive T-Lymphocytes/immunology; Cell Proliferation; Cells, Cultured; Graft Survival; Humans; Islets of Langerhans Transplantation/immunology; Mice; Mice, Inbred NOD; Mice, SCID; Microfilament Proteins; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein-Tyrosine Kinases; Tetanus Toxoid/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: CD4-Positive T-Lymphocytes / Leukocyte Common Antigens / CD8-Positive T-Lymphocytes / Antibodies, Monoclonal Limits: Animals / Humans Language: En Journal: J Exp Med Year: 2005 Type: Article Affiliation country: Italy

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