Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity.

Osei-Hyiaman, Douglas; DePetrillo, Michael; Pacher, Pál; Liu, Jie; Radaeva, Svetlana; Bátkai, Sándor; Harvey-White, Judith; Mackie, Ken; Offertáler, László; Wang, Lei; Kunos, George

Osei-Hyiaman, Douglas; DePetrillo, Michael; Pacher, Pál; Liu, Jie; Radaeva, Svetlana; Bátkai, Sándor; Harvey-White, Judith; Mackie, Ken; Offertáler, László; Wang, Lei; Kunos, George.

Affiliation

Osei-Hyiaman D; National Institute on Alcohol Abuse & Alcoholism, NIH, Bethesda, Maryland 20892, USA.

J Clin Invest ; 115(5): 1298-305, 2005 May.

Article in En | MEDLINE | ID: mdl-15864349

Subject(s)

Cannabinoid Receptor Modulators/metabolism; Diet; Endocannabinoids; Fatty Acids/biosynthesis; Liver/metabolism; Obesity/metabolism; Receptor, Cannabinoid, CB1/metabolism; Animals; Arachidonic Acids/pharmacology; CCAAT-Enhancer-Binding Proteins/metabolism; Cannabinoid Receptor Modulators/pharmacology; DNA-Binding Proteins/metabolism; Dietary Fats/metabolism; Fatty Liver/etiology; Fatty Liver/metabolism; Hypothalamus/metabolism; Mice; Obesity/etiology; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1/genetics; Sterol Regulatory Element Binding Protein 1; Transcription Factors/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptor, Cannabinoid, CB1 / Endocannabinoids / Diet / Fatty Acids / Cannabinoid Receptor Modulators / Liver / Obesity Type of study: Etiology_studies Limits: Animals Language: En Journal: J Clin Invest Year: 2005 Type: Article Affiliation country: United States

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