Increased lipolysis in non-obese pregnant women studied in the third trimester.
BJOG
; 112(6): 713-8, 2005 Jun.
Article
in En
| MEDLINE
| ID: mdl-15924525
ABSTRACT
BACKGROUND:
During pregnancy, metabolic adaptation takes place in the mother to provide for the supply of substrates to the growing fetus.OBJECTIVE:
To determine rates and endocrine regulation of lipolysis and glucose production (GPR) in late pregnancy.DESIGN:
Energy substrate production was measured in healthy pregnant women by use of stable isotope-labelled compounds.SETTING:
University Hospital, Uppsala, Sweden. SAMPLE Eight healthy non-obese, non-smoking women with normal pregnancies were studied at 33-36 weeks of gestation after an overnight (12-14 hours) fast.METHODS:
Rates of glycerol and glucose production were analysed by gas chromatography/mass spectrometry following constant rate infusion of [1,1,2,3,3-(2)H(5)]-glycerol and [6,6-(2)H(2)]-glucose. MAIN OUTCOMEMEASURE:
Glycerol and glucose production in the third trimester.RESULTS:
The mean rate of glycerol production, reflecting lipolysis, was 3.06 (0.66) and the mean GPR was 13.2 (1.5) micromol kg(-1) minute(-1) [2.38 (0.27) mg kg(-1) minute(-1)]. There was a correlation between rate of glycerol production and GPR (r = 0.75, P = 0.033). Fasting insulin levels correlated inversely with both the rate of glycerol production (r = -0.85, P = 0.008) and GPR (r = -0.78, P= 0.021).CONCLUSIONS:
Our results show that lipolysis is markedly increased during late pregnancy compared with reported data for non-pregnant women. The data also confirm the occurrence of an increased GPR in pregnant women. The finding of a correlation between rate of glycerol production and GPR corroborates the view that lipolysis promotes gluconeogenesis. Although late gestation is associated with insulin resistance, the results show that insulin plays a regulatory role both in lipolysis and glucose production.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Blood Glucose
/
Pregnancy
/
Lipolysis
Limits:
Adult
/
Female
/
Humans
Language:
En
Journal:
BJOG
Journal subject:
GINECOLOGIA
/
OBSTETRICIA
Year:
2005
Type:
Article
Affiliation country:
Sweden