Relationship between sodium channel NaV1.3 expression and neuropathic pain behavior in rats.

Lindia, Jill A; Köhler, Martin G; Martin, William J; Abbadie, Catherine

Lindia, Jill A; Köhler, Martin G; Martin, William J; Abbadie, Catherine.

Affiliation

Lindia JA; Merck Research Laboratories, Department of Pharmacology, P.O. Box 2000, Rahway, NJ 07065, USA.

Pain ; 117(1-2): 145-53, 2005 Sep.

Article in En | MEDLINE | ID: mdl-16061326

Subject(s)

Nerve Tissue Proteins/metabolism; Neurons/metabolism; Pain/psychology; Peripheral Nervous System Diseases/psychology; Sodium Channels/metabolism; Up-Regulation/physiology; Analgesics/therapeutic use; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Ganglia, Spinal/cytology; Ganglia, Spinal/metabolism; Immunohistochemistry/methods; Lamotrigine; Male; Mexiletine/therapeutic use; NAV1.3 Voltage-Gated Sodium Channel; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/physiology; Neurons/drug effects; Oligonucleotides/administration & dosage; Pain/drug therapy; Pain/etiology; Pain/metabolism; Pain Measurement/methods; Peripheral Nerves/metabolism; Peripheral Nervous System Diseases/complications; Peripheral Nervous System Diseases/drug therapy; Peripheral Nervous System Diseases/metabolism; Rats; Rats, Sprague-Dawley; Skin/metabolism; Sodium Channels/genetics; Sodium Channels/physiology; Time Factors; Triazines/therapeutic use; Up-Regulation/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Pain / Sodium Channels / Up-Regulation / Peripheral Nervous System Diseases / Nerve Tissue Proteins / Neurons Type of study: Etiology_studies / Prognostic_studies Language: En Journal: Pain Year: 2005 Type: Article Affiliation country: United States

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