HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability.

Isaacs, Jennifer S; Jung, Yun Jin; Mole, David R; Lee, Sunmin; Torres-Cabala, Carlos; Chung, Yuen-Li; Merino, Maria; Trepel, Jane; Zbar, Berton; Toro, Jorge; Ratcliffe, Peter J; Linehan, W Marston; Neckers, Len

Isaacs, Jennifer S; Jung, Yun Jin; Mole, David R; Lee, Sunmin; Torres-Cabala, Carlos; Chung, Yuen-Li; Merino, Maria; Trepel, Jane; Zbar, Berton; Toro, Jorge; Ratcliffe, Peter J; Linehan, W Marston; Neckers, Len.

Affiliation

Isaacs JS; Urologic Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA.

Cancer Cell ; 8(2): 143-53, 2005 Aug.

Article in En | MEDLINE | ID: mdl-16098467

Subject(s)

Carcinoma, Renal Cell/metabolism; DNA-Binding Proteins/metabolism; Fumarate Hydratase/genetics; Fumarates/metabolism; Kidney Neoplasms/metabolism; Leiomyomatosis/metabolism; Nuclear Proteins/metabolism; Transcription Factors/metabolism; Adult; Alleles; Basic Helix-Loop-Helix Transcription Factors; Carcinoma, Renal Cell/enzymology; Carcinoma, Renal Cell/genetics; DNA-Binding Proteins/analysis; DNA-Binding Proteins/genetics; Female; Fumarate Hydratase/antagonists & inhibitors; Fumarate Hydratase/metabolism; Fumarates/pharmacology; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Ketoglutaric Acids/pharmacology; Kidney Neoplasms/enzymology; Kidney Neoplasms/genetics; Leiomyomatosis/enzymology; Leiomyomatosis/genetics; Male; Middle Aged; Nuclear Proteins/analysis; Nuclear Proteins/genetics; Procollagen-Proline Dioxygenase/antagonists & inhibitors; Syndrome; Transcription Factors/analysis; Transcription Factors/genetics; Up-Regulation

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Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Nuclear Proteins / Carcinoma, Renal Cell / Leiomyomatosis / DNA-Binding Proteins / Fumarate Hydratase / Fumarates / Kidney Neoplasms Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Cancer Cell Journal subject: NEOPLASIAS Year: 2005 Type: Article Affiliation country: United States

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