The BRIP1 helicase functions independently of BRCA1 in the Fanconi anemia pathway for DNA crosslink repair.

Bridge, Wendy L; Vandenberg, Cassandra J; Franklin, Roger J; Hiom, Kevin

Bridge, Wendy L; Vandenberg, Cassandra J; Franklin, Roger J; Hiom, Kevin.

Affiliation

Bridge WL; Protein & Nucleic Acid Chemistry Division, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.

Nat Genet ; 37(9): 953-7, 2005 Sep.

Article in En | MEDLINE | ID: mdl-16116421

Subject(s)

BRCA1 Protein/metabolism; Chromosome Aberrations; DNA Repair; Fanconi Anemia/genetics; RNA Helicases/metabolism; Signal Transduction; Animals; Chickens; Cisplatin/pharmacology; Cross-Linking Reagents/pharmacology; DNA Damage/drug effects; DNA-Binding Proteins/chemistry; Fanconi Anemia/metabolism; Fanconi Anemia Complementation Group D2 Protein; Fanconi Anemia Complementation Group Proteins; G2 Phase/drug effects; HeLa Cells; Humans; Mitomycin/pharmacology; Nuclear Proteins/metabolism; RNA Helicases/antagonists & inhibitors; RNA Helicases/chemistry; RNA Helicases/genetics; RNA, Small Interfering/pharmacology; S Phase/drug effects; Ubiquitin/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Chromosome Aberrations / BRCA1 Protein / RNA Helicases / DNA Repair / Fanconi Anemia Limits: Animals / Humans Language: En Journal: Nat Genet Journal subject: GENETICA MEDICA Year: 2005 Type: Article Affiliation country: United kingdom

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