Photosensitizing properties of 6-methoxy-2-naphthylacetic acid, the major metabolite of the phototoxic non-steroidal anti-inflammatory and analgesic drug nabumetone.

Canudas, N; Zamora, D; Villamizar, J E; Fuentes, J; Castelli, C; Taddei, A

Canudas, N; Zamora, D; Villamizar, J E; Fuentes, J; Castelli, C; Taddei, A.

Affiliation

Canudas N; Laboratorio de Fotoquímica y Fotobiología, Departamento de Química, Universidad Simón Bolívar, Venezuela. ncanudas@usb.ve

Pharmazie ; 60(8): 604-8, 2005 Aug.

Article in En | MEDLINE | ID: mdl-16124404

Subject(s)

Anti-Inflammatory Agents, Non-Steroidal/pharmacokinetics; Butanones/pharmacokinetics; Dermatitis, Phototoxic; Naphthaleneacetic Acids/pharmacology; Photosensitizing Agents/pharmacology; Aerobiosis; Anaerobiosis; Candida/drug effects; Candida/growth & development; Candida/radiation effects; DNA/drug effects; DNA/radiation effects; Erythrocytes/drug effects; Erythrocytes/radiation effects; Hemolysis/drug effects; Hemolysis/radiation effects; Histidine/chemistry; Histidine/radiation effects; Humans; In Vitro Techniques; Light; Linoleic Acid/chemistry; Linoleic Acid/radiation effects; Lipid Peroxidation/drug effects; Lipid Peroxidation/radiation effects; Nabumetone; Nitroblue Tetrazolium/chemistry; Nitroblue Tetrazolium/radiation effects; Photochemistry; Thymine/chemistry; Thymine/radiation effects

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Collection: 01-internacional Database: MEDLINE Main subject: Butanones / Anti-Inflammatory Agents, Non-Steroidal / Photosensitizing Agents / Dermatitis, Phototoxic / Naphthaleneacetic Acids Limits: Humans Language: En Journal: Pharmazie Journal subject: FARMACIA Year: 2005 Type: Article Affiliation country: Venezuela

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