2-Amino-3,4-dimethylimidazo[4,5-f]quinoline induces and inhibits cytochrome P450 from the IA subfamily in chick and rat hepatocytes.

Sinclair, J F; Schaeffer, B K; Wood, S G; Lambrecht, L K; Gorman, N; Bement, W J; Smith, E L; Sinclair, P R; Waldren, C A

Sinclair, J F; Schaeffer, B K; Wood, S G; Lambrecht, L K; Gorman, N; Bement, W J; Smith, E L; Sinclair, P R; Waldren, C A.

Affiliation

Sinclair JF; VA Medical Center, White River Junction, Vermont 05009.

Cancer Res ; 52(13): 3615-21, 1992 Jul 01.

Article in En | MEDLINE | ID: mdl-1617633

Subject(s)

Cytochrome P-450 Enzyme System/analysis; Liver/drug effects; Mutagens; Quinolines/toxicity; Animals; Cells, Cultured; Chick Embryo; Cytochrome P-450 CYP1A1; Liver/enzymology; Male; Oxidoreductases/analysis; Rats; Rats, Inbred F344; Uroporphyrinogens/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Quinolines / Cytochrome P-450 Enzyme System / Liver / Mutagens Limits: Animals Language: En Journal: Cancer Res Year: 1992 Type: Article

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