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Structure-based design and discovery of protein tyrosine phosphatase inhibitors incorporating novel isothiazolidinone heterocyclic phosphotyrosine mimetics.
Combs, Andrew P; Yue, Eddy W; Bower, Michael; Ala, Paul J; Wayland, Brian; Douty, Brent; Takvorian, Amy; Polam, Padmaja; Wasserman, Zelda; Zhu, Wenyu; Crawley, Matthew L; Pruitt, James; Sparks, Richard; Glass, Brian; Modi, Dilip; McLaughlin, Erin; Bostrom, Lori; Li, Mei; Galya, Laurine; Blom, Karl; Hillman, Milton; Gonneville, Lucie; Reid, Brian G; Wei, Min; Becker-Pasha, Mary; Klabe, Ronald; Huber, Reid; Li, Yanlong; Hollis, Gregory; Burn, Timothy C; Wynn, Richard; Liu, Phillip; Metcalf, Brian.
Affiliation
  • Combs AP; Discovery Chemistry, Incyte Corporation, Experimental Station, E336/132A, Route 141 and Henry Clay Road, Wilmington, DE 19880, USA. acombs@incyte.com
J Med Chem ; 48(21): 6544-8, 2005 Oct 20.
Article in En | MEDLINE | ID: mdl-16220970
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Collection: 01-internacional Database: MEDLINE Main subject: Thiazoles / Protein Tyrosine Phosphatases / Phosphotyrosine / Dipeptides Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2005 Type: Article Affiliation country: United States
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Collection: 01-internacional Database: MEDLINE Main subject: Thiazoles / Protein Tyrosine Phosphatases / Phosphotyrosine / Dipeptides Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2005 Type: Article Affiliation country: United States