Evaluation of the efficacy of emodepside+praziquantel topical solution against cestode (Dipylidium caninum, Taenia taeniaeformis, and Echinococcus multilocularis) infections in cats.
Parasitol Res
; 97 Suppl 1: S33-S40, 2005 Oct.
Article
in En
| MEDLINE
| ID: mdl-16228273
ABSTRACT
Emodepside+praziquantel topical solution was developed to provide broad-spectrum anthelmintic activity against gastrointestinal parasites in cats. Eight controlled studies were conducted to evaluate the efficacy of a topical solution of emodepside (3 mg/kg) and praziquantel (12 mg/kg) (Profender, BayerAG, Leverkusen, Germany) against feline infections with three species of cestodes. Studies featured naturally acquired infections of Dipylidium caninum or Taenia taeniaeformis, or experimental infections with Echinococcus multilocularis that were placebo-controlled, randomized and blinded. Cats were euthanatized and necropsied between 2 and 11 days after treatment, depending on the target parasite. The efficacy of emodepside+praziquantel topical solution was 100% against D. caninum and T. taeniaeformis, and 98.5- 100% against E. multilocularis. No significant systemic or local adverse reactions to treatment were noted in cats that received the combination. Topical treatment of cats with emodepside+praziquantel topical solution was safe and highly effective against cestode infections.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Praziquantel
/
Cat Diseases
/
Cestode Infections
/
Depsipeptides
Limits:
Animals
Language:
En
Journal:
Parasitol Res
Journal subject:
PARASITOLOGIA
Year:
2005
Type:
Article
Affiliation country:
United States