Evaluation of the efficacy of emodepside plus praziquantel topical solution against ascarid infections (Toxocara cati or Toxascaris leonina) in cats.
Parasitol Res
; 97 Suppl 1: S41-S50, 2005 Oct.
Article
in En
| MEDLINE
| ID: mdl-16228274
ABSTRACT
Eleven controlled studies were conducted in the United States and Europe to evaluate the efficacy of a topical solution of emodepside (3 mg/kg)+praziquantel (12 mg/kg) (Profender, Bayer AG, Leverkusen, Germany) against infection with various stages of the ascarid nematodes Toxocara cati and Toxascaris leonina. Infections were induced by administration of larvated ascarid eggs, and stage-specific efficacy was evaluated by treating cats at scheduled intervals post-inoculation. All studies featured random allocation to treatment groups, placebo-treated control animals and assessment of outcome measures by masked personnel. The product (emodepside+praziquantel topical solution) was 100% effective against mature adults and immature adult T. cati. In addition, it was 96.8% effective against third stage larvae and at least 99.4% effective against fourth stage larvae of T. cati, respectively. Efficacy against mature, immature adult and L4 stages of T. leonina exceeded 93.4%, but regulatory "adequacy of infection" criteria were not met in some studies. No adverse reactions to treatment were noted in cats treated with the emodepside+praziquantel topical solution.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Praziquantel
/
Cat Diseases
/
Toxocariasis
/
Depsipeptides
Limits:
Animals
Language:
En
Journal:
Parasitol Res
Journal subject:
PARASITOLOGIA
Year:
2005
Type:
Article
Affiliation country:
United States