The anti-angiogenesis agent, AG-013736, has minimal activity in elderly patients with poor prognosis acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS).

Giles, Francis J; Bellamy, William T; Estrov, Zeev; O'Brien, Susan M; Verstovsek, Srdan; Ravandi, Farhad; Beran, Miloslav; Bycott, Paul; Pithavala, Yazdi; Steinfeldt, Heidi; Reich, Steven D; List, Alan F; Yee, Karen W L

Giles, Francis J; Bellamy, William T; Estrov, Zeev; O'Brien, Susan M; Verstovsek, Srdan; Ravandi, Farhad; Beran, Miloslav; Bycott, Paul; Pithavala, Yazdi; Steinfeldt, Heidi; Reich, Steven D; List, Alan F; Yee, Karen W L.

Affiliation

Giles FJ; Department of Leukemia, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Box 428, Houston, TX 77030, USA. frankgiles@aol.com

Leuk Res ; 30(7): 801-11, 2006 Jul.

Article in En | MEDLINE | ID: mdl-16332390

Subject(s)

Angiogenesis Inhibitors/administration & dosage; Antineoplastic Agents/administration & dosage; Imidazoles/administration & dosage; Indazoles/administration & dosage; Leukemia, Myeloid/drug therapy; Myelodysplastic Syndromes/drug therapy; Acute Disease; Administration, Oral; Aged; Aged, 80 and over; Angiogenesis Inhibitors/adverse effects; Angiogenesis Inhibitors/pharmacokinetics; Antineoplastic Agents/adverse effects; Antineoplastic Agents/pharmacokinetics; Axitinib; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Imidazoles/adverse effects; Imidazoles/pharmacokinetics; Immunohistochemistry; Indazoles/adverse effects; Indazoles/pharmacokinetics; Leukemia, Myeloid/diagnosis; Male; Middle Aged; Myelodysplastic Syndromes/diagnosis; Placenta Growth Factor; Predictive Value of Tests; Pregnancy Proteins/antagonists & inhibitors; Pregnancy Proteins/blood; Prognosis; Proto-Oncogene Proteins c-kit/blood; Proto-Oncogene Proteins c-kit/drug effects; Treatment Outcome; Vascular Endothelial Growth Factor Receptor-1/antagonists & inhibitors; Vascular Endothelial Growth Factor Receptor-1/blood; Vascular Endothelial Growth Factor Receptor-2/antagonists & inhibitors; Vascular Endothelial Growth Factor Receptor-2/blood

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Collection: 01-internacional Database: MEDLINE Main subject: Myelodysplastic Syndromes / Leukemia, Myeloid / Angiogenesis Inhibitors / Imidazoles / Indazoles / Antineoplastic Agents Type of study: Diagnostic_studies / Prognostic_studies Limits: Aged80 Language: En Journal: Leuk Res Year: 2006 Type: Article Affiliation country: United States

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