Aurora-A overexpression associates with Ha-ras codon-12 mutation and blackfoot disease endemic area in bladder cancer.
Cancer Lett
; 241(1): 93-101, 2006 Sep 08.
Article
in En
| MEDLINE
| ID: mdl-16338065
ABSTRACT
Our data revealed that 59.4% of the bladder cancer specimens showed Aurora-A overexpression, of which 31.8% also had Ha-ras codon-12 mutation; 45.5% were from blackfoot-disease endemic areas in which arsenic exposure is a major environment factor associated with various cancer formation. We further demonstrated that arsenic treatment of the immortalized bladder cell line, E7, increased Aurora-A expression. All together, co-existence of Aurora-A overexpression and Ha-ras mutation suggests a possible additively effect on the tumorigenesis of bladder cancer. In addition, Aurora-A overexpression and up-regulated by arsenic exposure opens a new direction for exploring the occurrence of bladder cancer occurrence in Taiwan.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Codon
/
Genes, ras
/
Peripheral Vascular Diseases
/
Protein Serine-Threonine Kinases
/
Mutation
Type of study:
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Cancer Lett
Year:
2006
Type:
Article