Restoring function in exhausted CD8 T cells during chronic viral infection.

Barber, Daniel L; Wherry, E John; Masopust, David; Zhu, Baogong; Allison, James P; Sharpe, Arlene H; Freeman, Gordon J; Ahmed, Rafi

Barber, Daniel L; Wherry, E John; Masopust, David; Zhu, Baogong; Allison, James P; Sharpe, Arlene H; Freeman, Gordon J; Ahmed, Rafi.

Affiliation

Barber DL; Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

Nature ; 439(7077): 682-7, 2006 Feb 09.

Article in En | MEDLINE | ID: mdl-16382236

Subject(s)

CD8-Positive T-Lymphocytes/immunology; Virus Diseases/immunology; Animals; Antigens, CD; Antigens, Differentiation/immunology; Antigens, Surface/genetics; Antigens, Surface/metabolism; Apoptosis Regulatory Proteins/genetics; Apoptosis Regulatory Proteins/metabolism; B7-1 Antigen/genetics; B7-1 Antigen/metabolism; B7-H1 Antigen; CD8-Positive T-Lymphocytes/cytology; CTLA-4 Antigen; Cell Proliferation; Chronic Disease; Gene Expression Regulation; Immune Tolerance/immunology; Lymphocytic Choriomeningitis/immunology; Lymphocytic choriomeningitis virus/immunology; Lymphocytic choriomeningitis virus/physiology; Membrane Glycoproteins/deficiency; Membrane Glycoproteins/genetics; Membrane Glycoproteins/metabolism; Mice; Peptides/deficiency; Peptides/genetics; Peptides/metabolism; Programmed Cell Death 1 Receptor; Substrate Specificity

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Collection: 01-internacional Database: MEDLINE Main subject: Virus Diseases / CD8-Positive T-Lymphocytes Type of study: Prognostic_studies Limits: Animals Language: En Journal: Nature Year: 2006 Type: Article Affiliation country: United States

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