Synthesis and insecticidal activity of fluorinated 2-(2,6-dichloro-4-trifluoromethylphenyl)-2,4,5,6-tetrahydrocyclopentapyrazoles.

Meegalla, Sanath K; Doller, Dario; Liu, Ruiping; Sha, DeYou; Lee, YuKai; Soll, Richard M; Wisnewski, Nancy; Silver, Gary M; Dhanoa, Dale

Meegalla, Sanath K; Doller, Dario; Liu, Ruiping; Sha, DeYou; Lee, YuKai; Soll, Richard M; Wisnewski, Nancy; Silver, Gary M; Dhanoa, Dale.

Affiliation

Meegalla SK; Johnson & Johnson Pharmaceutical Research and Development, 665 Stockton Drive, Suite 104, Exton, PA 19341, USA. smeegall@prdus.jnj.com

Bioorg Med Chem Lett ; 16(6): 1702-6, 2006 Mar 15.

Article in En | MEDLINE | ID: mdl-16386419

ABSTRACT

ABSTRACT

A number of fluorinated 1-aryl-tetrahydrocyclopentapyrazoles were synthesized and their insecticidal activity was evaluated. Some of the fluorinated compounds had significant insecticidal properties.

Subject(s)

Insecta/drug effects; Insecticides/chemical synthesis; Insecticides/toxicity; Pyrazoles/chemical synthesis; Pyrazoles/toxicity; Animals; Brain/drug effects; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane/metabolism; Houseflies/drug effects; Houseflies/growth & development; Insecticides/chemistry; Mice; Molecular Structure; Neurons/drug effects; Pyrazoles/chemistry; Radioligand Assay; Receptors, GABA/metabolism; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Insecticides / Insecta Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2006 Type: Article Affiliation country: United States

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