Prostaglandin J2 reduces catechol-O-methyltransferase activity and enhances dopamine toxicity in neuronal cells.

Ogburn, Kenyon D; Bottiglieri, Teodoro; Wang, Zhiyou; Figueiredo-Pereira, Maria E

Ogburn, Kenyon D; Bottiglieri, Teodoro; Wang, Zhiyou; Figueiredo-Pereira, Maria E.

Affiliation

Ogburn KD; Department of Biological Sciences, Hunter College of City University of New York, 695 Park Avenue, New York, NY 10021, USA.

Neurobiol Dis ; 22(2): 294-301, 2006 May.

Article in En | MEDLINE | ID: mdl-16406650

Subject(s)

Catechol O-Methyltransferase Inhibitors; Dopamine/toxicity; Encephalitis/metabolism; Nerve Degeneration/metabolism; Neurons/metabolism; Prostaglandin D2/analogs & derivatives; Animals; Brain Damage, Chronic/metabolism; Brain Damage, Chronic/physiopathology; Catechol O-Methyltransferase/metabolism; Catecholamines/metabolism; Cell Line, Tumor; Cerebral Cortex/metabolism; Cerebral Cortex/pathology; Cerebral Cortex/physiopathology; Dopamine/metabolism; Down-Regulation/drug effects; Down-Regulation/physiology; Encephalitis/chemically induced; Encephalitis/physiopathology; Humans; Inclusion Bodies/drug effects; Inclusion Bodies/metabolism; Inflammation Mediators/metabolism; Inflammation Mediators/pharmacology; Nerve Degeneration/chemically induced; Nerve Degeneration/physiopathology; Neurons/drug effects; Neurons/pathology; Oxidative Stress/drug effects; Oxidative Stress/physiology; Prostaglandin D2/metabolism; Prostaglandin D2/pharmacology; Rats

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Collection: 01-internacional Database: MEDLINE Main subject: Prostaglandin D2 / Dopamine / Encephalitis / Catechol O-Methyltransferase Inhibitors / Nerve Degeneration / Neurons Type of study: Risk_factors_studies Limits: Animals / Humans Language: En Journal: Neurobiol Dis Journal subject: NEUROLOGIA Year: 2006 Type: Article Affiliation country: United States

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