Discovery of two novel, small-molecule inhibitors of DNA methylation.

Siedlecki, Pawel; Garcia Boy, Regine; Musch, Tanja; Brueckner, Bodo; Suhai, Sandor; Lyko, Frank; Zielenkiewicz, Piotr

Siedlecki, Pawel; Garcia Boy, Regine; Musch, Tanja; Brueckner, Bodo; Suhai, Sandor; Lyko, Frank; Zielenkiewicz, Piotr.

Affiliation

Siedlecki P; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5a, 02-106 Warsaw, Poland.

J Med Chem ; 49(2): 678-83, 2006 Jan 26.

Article in En | MEDLINE | ID: mdl-16420053

Subject(s)

DNA (Cytosine-5-)-Methyltransferases/antagonists & inhibitors; DNA (Cytosine-5-)-Methyltransferases/chemistry; DNA Methylation; Indoles/chemistry; Models, Molecular; Phthalimides/chemistry; Pyridines/chemistry; Triazoles/chemistry; Catalytic Domain; DNA (Cytosine-5-)-Methyltransferase 1; Humans

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Collection: 01-internacional Database: MEDLINE Main subject: Phthalimides / Pyridines / Triazoles / Models, Molecular / DNA Methylation / DNA (Cytosine-5-)-Methyltransferases / Indoles Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2006 Type: Article Affiliation country: Poland

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