Limited generation of activated protein C during infusion of the protein C activator thrombin analog W215A/E217A in primates.

Gruber, A; Fernández, J A; Bush, L; Marzec, U; Griffin, J H; Hanson, S R; DI Cera, E

Gruber, A; Fernández, J A; Bush, L; Marzec, U; Griffin, J H; Hanson, S R; DI Cera, E.

Affiliation

Gruber A; Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97006-8921, USA. grubera@ohsu.edu

J Thromb Haemost ; 4(2): 392-7, 2006 Feb.

Article in En | MEDLINE | ID: mdl-16420571

Subject(s)

Protein C/metabolism; Thrombin/pharmacology; Amino Acid Substitution; Animals; Anticoagulants/administration & dosage; Anticoagulants/pharmacology; Hemostasis/drug effects; Humans; Infusions, Intravenous; Injections, Intravenous; Mutagenesis, Site-Directed; Papio; Recombinant Proteins/administration & dosage; Recombinant Proteins/genetics; Recombinant Proteins/pharmacology; Thrombin/administration & dosage; Thrombin/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: Protein C / Thrombin Limits: Animals / Humans Language: En Journal: J Thromb Haemost Journal subject: HEMATOLOGIA Year: 2006 Type: Article Affiliation country: United States

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