Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development.

Kasper, Lawryn H; Fukuyama, Tomofusa; Biesen, Michelle A; Boussouar, Fayçal; Tong, Caili; de Pauw, Antoine; Murray, Peter J; van Deursen, Jan M A; Brindle, Paul K

Kasper, Lawryn H; Fukuyama, Tomofusa; Biesen, Michelle A; Boussouar, Fayçal; Tong, Caili; de Pauw, Antoine; Murray, Peter J; van Deursen, Jan M A; Brindle, Paul K.

Affiliation

Kasper LH; Department of Biochemistry, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105, USA.

Mol Cell Biol ; 26(3): 789-809, 2006 Feb.

Article in En | MEDLINE | ID: mdl-16428436

Subject(s)

CD4-Positive T-Lymphocytes/cytology; CD8-Positive T-Lymphocytes/cytology; CREB-Binding Protein/physiology; E1A-Associated p300 Protein/physiology; Thymus Gland/growth & development; Alleles; Animals; CD4-Positive T-Lymphocytes/drug effects; CD4-Positive T-Lymphocytes/metabolism; CD8-Positive T-Lymphocytes/drug effects; CD8-Positive T-Lymphocytes/metabolism; CREB-Binding Protein/genetics; Cell Differentiation; E1A-Associated p300 Protein/genetics; Gene Deletion; Gene Expression; Ionophores/pharmacology; Lymphocyte Count; Lymphoma, T-Cell/genetics; Macrophages/metabolism; Mice; Mice, Knockout; Phorbol Esters/pharmacology; Receptors, Antigen, T-Cell; Spleen/cytology; Spleen/growth & development; Thymus Gland/cytology; Transcription, Genetic; Tumor Necrosis Factor-alpha/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thymus Gland / CD4-Positive T-Lymphocytes / CD8-Positive T-Lymphocytes / CREB-Binding Protein / E1A-Associated p300 Protein Limits: Animals Language: En Journal: Mol Cell Biol Year: 2006 Type: Article Affiliation country: United States

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