Potassium channel subunit remodeling in rabbits exposed to long-term bradycardia or tachycardia: discrete arrhythmogenic consequences related to differential delayed-rectifier changes.

Tsuji, Yukiomi; Zicha, Stephen; Qi, Xiao-Yan; Kodama, Itsuo; Nattel, Stanley

Tsuji, Yukiomi; Zicha, Stephen; Qi, Xiao-Yan; Kodama, Itsuo; Nattel, Stanley.

Affiliation

Tsuji Y; Research Center, Department of Medicine, Montreal Heart Institute, University of Montreal, Montreal, Quebec, Canada.

Circulation ; 113(3): 345-55, 2006 Jan 24.

Article in En | MEDLINE | ID: mdl-16432066

Subject(s)

Bradycardia/physiopathology; Delayed Rectifier Potassium Channels/genetics; Delayed Rectifier Potassium Channels/physiology; Tachycardia, Ventricular/physiopathology; Animals; Bradycardia/diagnosis; Delayed Rectifier Potassium Channels/chemistry; Down-Regulation; Electrocardiography; KCNQ1 Potassium Channel/chemistry; KCNQ1 Potassium Channel/genetics; KCNQ1 Potassium Channel/physiology; Kv1.4 Potassium Channel/chemistry; Kv1.4 Potassium Channel/genetics; Kv1.4 Potassium Channel/physiology; Long QT Syndrome/diagnosis; Long QT Syndrome/physiopathology; Pacemaker, Artificial; Patch-Clamp Techniques; Protein Subunits/genetics; Protein Subunits/physiology; Rabbits; Shal Potassium Channels/chemistry; Shal Potassium Channels/genetics; Shal Potassium Channels/physiology; Tachycardia, Ventricular/diagnosis; Torsades de Pointes/diagnosis; Torsades de Pointes/physiopathology

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Collection: 01-internacional Database: MEDLINE Main subject: Bradycardia / Tachycardia, Ventricular / Delayed Rectifier Potassium Channels Type of study: Diagnostic_studies Limits: Animals Language: En Journal: Circulation Year: 2006 Type: Article Affiliation country: Canada

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