Ultra-performance liquid chromatography coupled to time-of-flight mass spectrometry for robust, high-throughput quantitative analysis of an automated metabolic stability assay, with simultaneous determination of metabolic data.

O'Connor, Desmond; Mortishire-Smith, Russell; Morrison, Denise; Davies, Amy; Dominguez, Maria

O'Connor, Desmond; Mortishire-Smith, Russell; Morrison, Denise; Davies, Amy; Dominguez, Maria.

Affiliation

O'Connor D; Merck Sharp & Dohme Research Laboratories, Department of Medicinal Chemistry (Drug Metabolism Section), Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK. desmond_oconnor@merck.com

Rapid Commun Mass Spectrom ; 20(5): 851-7, 2006.

Article in En | MEDLINE | ID: mdl-16470510

Subject(s)

Chromatography, High Pressure Liquid/methods; Diazepam/metabolism; Enkephalin, Leucine/metabolism; Imipramine/metabolism; Neurotransmitter Agents/metabolism; Psychotropic Drugs/metabolism; Spectrometry, Mass, Electrospray Ionization/methods; Animals; Drug Evaluation, Preclinical/methods; Drug Stability; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity

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Collection: 01-internacional Database: MEDLINE Main subject: Psychotropic Drugs / Enkephalin, Leucine / Chromatography, High Pressure Liquid / Neurotransmitter Agents / Spectrometry, Mass, Electrospray Ionization / Diazepam / Imipramine Type of study: Diagnostic_studies Limits: Animals Language: En Journal: Rapid Commun Mass Spectrom Year: 2006 Type: Article Affiliation country: United kingdom

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