Alkynyl pyrimidines as dual EGFR/ErbB2 kinase inhibitors.

Waterson, Alex G; Stevens, Kirk L; Reno, Michael J; Zhang, Yue-Mei; Boros, Eric E; Bouvier, Frederic; Rastagar, Abdullah; Uehling, David E; Dickerson, Scott H; Reep, Bryan; McDonald, Octerloney B; Wood, Edgar R; Rusnak, David W; Alligood, Krystal J; Rudolph, Sharon K

Waterson, Alex G; Stevens, Kirk L; Reno, Michael J; Zhang, Yue-Mei; Boros, Eric E; Bouvier, Frederic; Rastagar, Abdullah; Uehling, David E; Dickerson, Scott H; Reep, Bryan; McDonald, Octerloney B; Wood, Edgar R; Rusnak, David W; Alligood, Krystal J; Rudolph, Sharon K.

Affiliation

Waterson AG; GlaxoSmithKline, Five Moore Drive, Research Triangle Park, NC 27709-3398, USA. Alex.G.Waterson@gsk.com

Bioorg Med Chem Lett ; 16(9): 2419-22, 2006 May 01.

Article in En | MEDLINE | ID: mdl-16483772

Subject(s)

Alkynes/chemistry; ErbB Receptors/antagonists & inhibitors; Pyrimidines/pharmacology; Receptor, ErbB-2/antagonists & inhibitors; Cell Line, Tumor; Cell Proliferation/drug effects; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Molecular Structure; Pyrimidines/chemical synthesis; Pyrimidines/chemistry; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Receptor, ErbB-2 / Alkynes / ErbB Receptors Type of study: Prognostic_studies Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2006 Type: Article Affiliation country: United States

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