Targeting HSP90 to halt neurodegeneration.
Chem Biol
; 13(2): 115-6, 2006 Feb.
Article
in En
| MEDLINE
| ID: mdl-16492558
ABSTRACT
Activation of c-jun N-terminal kinase (JNK) signaling is associated with neuronal cell death. As described in this issue of Chemistry & Biology, cell-based screening efforts yielded a compound, AEG3482, which interacts with heat shock protein 90 leading to inhibition of JNK and blockade of neuronal apoptosis .
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sulfonamides
/
Thiadiazoles
/
Neuroprotective Agents
/
HSP90 Heat-Shock Proteins
/
Neurodegenerative Diseases
/
Enzyme Inhibitors
Limits:
Animals
/
Humans
Language:
En
Journal:
Chem Biol
Journal subject:
BIOLOGIA
/
BIOQUIMICA
/
QUIMICA
Year:
2006
Type:
Article
Affiliation country:
United States