Mechanisms and biomarkers of cardiovascular injury induced by phosphodiesterase inhibitor III SK&F 95654 in the spontaneously hypertensive rat.

Zhang, Jun; Herman, Eugene H; Robertson, Donald G; Reily, Michael D; Knapton, Alan; Ratajczak, Helen V; Rifai, Nader; Honchel, Ronald; Blanchard, Kerry T; Stoll, Raymond E; Sistare, Frank D

Zhang, Jun; Herman, Eugene H; Robertson, Donald G; Reily, Michael D; Knapton, Alan; Ratajczak, Helen V; Rifai, Nader; Honchel, Ronald; Blanchard, Kerry T; Stoll, Raymond E; Sistare, Frank D.

Affiliation

Zhang J; Division of Applied Pharmacology Research (HFD-910), Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993, USA. jun.zhang@fda.hhs.gov

Toxicol Pathol ; 34(2): 152-63, 2006.

Article in En | MEDLINE | ID: mdl-16537294

Subject(s)

Biomarkers/analysis; Cardiovascular Diseases/chemically induced; Cardiovascular System/drug effects; Phosphodiesterase Inhibitors/toxicity; Pyridazines/toxicity; Pyridines/toxicity; Alanine Transaminase/blood; Animals; Apoptosis/drug effects; Aspartate Aminotransferases/blood; Cardiovascular Diseases/blood; Cardiovascular Diseases/urine; Cardiovascular System/pathology; Creatine/urine; Endothelial Cells/drug effects; Endothelial Cells/pathology; Hippurates/urine; Immunohistochemistry; Interleukin-6/blood; Male; Mast Cells/drug effects; Mast Cells/pathology; Myocytes, Cardiac/chemistry; Myocytes, Cardiac/drug effects; Myocytes, Cardiac/pathology; Phosphodiesterase Inhibitors/pharmacology; Pyridazines/pharmacology; Pyridines/pharmacology; Rats; Rats, Inbred SHR; Taurine/urine; Troponin/analysis; Troponin/blood; Tumor Necrosis Factor-alpha/analysis; alpha-Macroglobulins/analysis

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Collection: 01-internacional Database: MEDLINE Main subject: Phosphodiesterase Inhibitors / Pyridazines / Pyridines / Biomarkers / Cardiovascular Diseases / Cardiovascular System Limits: Animals Language: En Journal: Toxicol Pathol Year: 2006 Type: Article Affiliation country: United States

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