Efficacy of 2-halogen substituted D-glucose analogs in blocking glycolysis and killing "hypoxic tumor cells".

Lampidis, Theodore J; Kurtoglu, Metin; Maher, Johnathan C; Liu, Huaping; Krishan, Awtar; Sheft, Valerie; Szymanski, Slawomir; Fokt, Izabela; Rudnicki, Witold R; Ginalski, Krzysztof; Lesyng, Bogdan; Priebe, Waldemar

Lampidis, Theodore J; Kurtoglu, Metin; Maher, Johnathan C; Liu, Huaping; Krishan, Awtar; Sheft, Valerie; Szymanski, Slawomir; Fokt, Izabela; Rudnicki, Witold R; Ginalski, Krzysztof; Lesyng, Bogdan; Priebe, Waldemar.

Affiliation

Lampidis TJ; School of Medicine and Sylvester Cancer Center, The University of Miami, Miami, FL, USA.

Cancer Chemother Pharmacol ; 58(6): 725-34, 2006 Dec.

Article in En | MEDLINE | ID: mdl-16555088

Subject(s)

Cell Proliferation/drug effects; Deoxyglucose/pharmacology; Glycolysis/drug effects; Halogens/chemistry; Cell Hypoxia; Cell Line, Tumor; Cell Survival/drug effects; Deoxyglucose/analogs & derivatives; Deoxyglucose/chemistry; Drug Design; Fluorodeoxyglucose F18/chemistry; Fluorodeoxyglucose F18/pharmacology; Glucose-6-Phosphate/analogs & derivatives; Glucose-6-Phosphate/chemistry; Glucose-6-Phosphate/metabolism; Hexokinase/chemistry; Hexokinase/metabolism; Humans; Lactic Acid/chemistry; Lactic Acid/metabolism; Models, Molecular; Quantitative Structure-Activity Relationship; Thermodynamics

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Collection: 01-internacional Database: MEDLINE Main subject: Deoxyglucose / Cell Proliferation / Glycolysis / Halogens Type of study: Guideline Limits: Humans Language: En Journal: Cancer Chemother Pharmacol Year: 2006 Type: Article Affiliation country: United States

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