Molecular mechanism for pterin-mediated inactivation of tyrosine hydroxylase: formation of insoluble aggregates of tyrosine hydroxylase.

Urano, Fumi; Hayashi, Nobuhiro; Arisaka, Fumio; Kurita, Hideki; Murata, Shizuaki; Ichinose, Hiroshi

Urano, Fumi; Hayashi, Nobuhiro; Arisaka, Fumio; Kurita, Hideki; Murata, Shizuaki; Ichinose, Hiroshi.

Affiliation

Urano F; Department of Life Science, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama 226-8501.

J Biochem ; 139(4): 625-35, 2006 Apr.

Article in En | MEDLINE | ID: mdl-16672262

Subject(s)

Pterins/pharmacology; Tyrosine 3-Monooxygenase/metabolism; Biopterins/analogs & derivatives; Biopterins/metabolism; Biopterins/pharmacology; Centrifugation, Density Gradient; Chromatography, Gel; Circular Dichroism; Dopamine/metabolism; Dopamine/pharmacology; Electrophoresis, Polyacrylamide Gel; Enzyme Activation/drug effects; Humans; Kinetics; Microscopy, Electron, Transmission; Models, Chemical; Pterins/metabolism; Recombinant Proteins/antagonists & inhibitors; Recombinant Proteins/metabolism; Spectrometry, Fluorescence; Tyrosine 3-Monooxygenase/genetics; Tyrosine 3-Monooxygenase/ultrastructure

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Collection: 01-internacional Database: MEDLINE Main subject: Pterins / Tyrosine 3-Monooxygenase Limits: Humans Language: En Journal: J Biochem Year: 2006 Type: Article

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PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Pterins / Tyrosine 3-Monooxygenase Limits: Humans Language: En Journal: J Biochem Year: 2006 Type: Article