First case of ivermectin-induced severe hepatitis.
Trans R Soc Trop Med Hyg
; 100(8): 795-7, 2006 Aug.
Article
in En
| MEDLINE
| ID: mdl-16682062
ABSTRACT
Loiasis, caused by the filarial parasite Loa loa, is endemic in West and Central Africa. Ivermectin has been shown to be an effective treatment of loiasis. We report the case of a 20-year-old woman originally from Cameroon who was infected by the L. loa parasite and developed severe hepatitis, identified 1 month after a single dose of ivermectin. Liver biopsy showed intralobular inflammatory infiltrates, confluent necrosis and apoptosis, compatible with drug-induced liver disease. To our knowledge, this is the first case of ivermectin-induced severe liver disease published in the literature.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ivermectin
/
Loiasis
/
Chemical and Drug Induced Liver Injury
/
Antiparasitic Agents
Type of study:
Prognostic_studies
Limits:
Adult
/
Animals
/
Female
/
Humans
Country/Region as subject:
Africa
Language:
En
Journal:
Trans R Soc Trop Med Hyg
Year:
2006
Type:
Article
Affiliation country:
Switzerland