Immunohistochemical detection of EGF and NGF receptors in human olfactory epithelium.
Boll Soc Ital Biol Sper
; 67(10-11): 901-6, 1991.
Article
in En
| MEDLINE
| ID: mdl-1668217
ABSTRACT
The immunohistochemical localization of EGF and NGF receptors has been studied in the olfactory epithelium of human foetuses from 8 to 12 weeks of age. A positivity for EGF receptor, increasing with the age, was detected in the apical portion of the sensory epithelium. The NGF receptor was well detectable also at 8 weeks and localized both in differentiated olfactory cells and in some basal cells. From primary cultures of olfactory epithelium, a cell clone positive for Enolase, Neurofilaments and S-100 Protein was identified. These cells were shown to be reactive for EGF and NGF receptors. The addition of Retinoic acid to the culture medium induces a morphological differentiation of these cells that become positive for the Olfactory Marker Protein.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Olfactory Mucosa
/
Receptors, Cell Surface
/
ErbB Receptors
Type of study:
Diagnostic_studies
/
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Boll Soc Ital Biol Sper
Year:
1991
Type:
Article