Chimpanzee reservoirs of pandemic and nonpandemic HIV-1.
Science
; 313(5786): 523-6, 2006 Jul 28.
Article
in En
| MEDLINE
| ID: mdl-16728595
ABSTRACT
Human immunodeficiency virus type 1 (HIV-1), the cause of human acquired immunodeficiency syndrome (AIDS), is a zoonotic infection of staggering proportions and social impact. Yet uncertainty persists regarding its natural reservoir. The virus most closely related to HIV-1 is a simian immunodeficiency virus (SIV) thus far identified only in captive members of the chimpanzee subspecies Pan troglodytes troglodytes. Here we report the detection of SIVcpz antibodies and nucleic acids in fecal samples from wild-living P. t. troglodytes apes in southern Cameroon, where prevalence rates in some communities reached 29 to 35%. By sequence analysis of endemic SIVcpz strains, we could trace the origins of pandemic (group M) and nonpandemic (group N) HIV-1 to distinct, geographically isolated chimpanzee communities. These findings establish P. t. troglodytes as a natural reservoir of HIV-1.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Disease Reservoirs
/
HIV Infections
/
Pan troglodytes
/
Disease Outbreaks
/
Simian Acquired Immunodeficiency Syndrome
/
HIV-1
/
Simian Immunodeficiency Virus
Type of study:
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Animals
/
Humans
Country/Region as subject:
Africa
Language:
En
Journal:
Science
Year:
2006
Type:
Article
Affiliation country:
United States