Mutations at the same residue (R50) of Kir6.2 (KCNJ11) that cause neonatal diabetes produce different functional effects.

Shimomura, Kenju; Girard, Christophe A J; Proks, Peter; Nazim, Joanna; Lippiat, Jonathan D; Cerutti, Franco; Lorini, Renata; Ellard, Sian; Hattersley, Andrew T; Barbetti, Fabrizio; Ashcroft, Frances M

Shimomura, Kenju; Girard, Christophe A J; Proks, Peter; Nazim, Joanna; Lippiat, Jonathan D; Cerutti, Franco; Lorini, Renata; Ellard, Sian; Hattersley, Andrew T; Barbetti, Fabrizio; Ashcroft, Frances M.

Affiliation

Shimomura K; University Laboratory of Physiology, Oxford University, Parks Road, Oxford OX1 3PT, UK.

Diabetes ; 55(6): 1705-12, 2006 Jun.

Article in En | MEDLINE | ID: mdl-16731833

Subject(s)

Arginine/genetics; Diabetes Mellitus/genetics; Mutation; Potassium Channels, Inwardly Rectifying/physiology; Adenosine Triphosphate/metabolism; Adenosine Triphosphate/pharmacology; Animals; Electrophysiology; Female; Heterozygote; Humans; Infant, Newborn; Kinetics; Magnesium/pharmacology; Male; Membrane Potentials/drug effects; Models, Molecular; Oocytes/drug effects; Oocytes/metabolism; Oocytes/physiology; Potassium Channels, Inwardly Rectifying/chemistry; Potassium Channels, Inwardly Rectifying/genetics; Protein Structure, Secondary; Rats; Sulfonylurea Compounds/pharmacology; Xenopus laevis

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Collection: 01-internacional Database: MEDLINE Main subject: Arginine / Potassium Channels, Inwardly Rectifying / Diabetes Mellitus / Mutation Limits: Animals / Female / Humans / Male / Newborn Language: En Journal: Diabetes Year: 2006 Type: Article Affiliation country: United kingdom

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