Raf plus TGFbeta-dependent EMT is initiated by endocytosis and lysosomal degradation of E-cadherin.

Janda, E; Nevolo, M; Lehmann, K; Downward, J; Beug, H; Grieco, M

Janda, E; Nevolo, M; Lehmann, K; Downward, J; Beug, H; Grieco, M.

Affiliation

Janda E; Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi Magna Graecia, Campus Germaneto, Catanzaro, Italy.

Oncogene ; 25(54): 7117-30, 2006 Nov 16.

Article in En | MEDLINE | ID: mdl-16751808

Subject(s)

Cadherins/metabolism; Cell Transformation, Neoplastic; Epithelial Cells/metabolism; Transforming Growth Factor beta/metabolism; raf Kinases/metabolism; Animals; Blotting, Northern; Blotting, Western; Cell Line, Tumor; Down-Regulation; Endocytosis; Epithelial Cells/pathology; Fluorescent Antibody Technique; Immunoprecipitation; Lysosomes/metabolism; Mice; Microscopy, Confocal; Protein Processing, Post-Translational; Recombinant Fusion Proteins

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Collection: 01-internacional Database: MEDLINE Main subject: Cadherins / Cell Transformation, Neoplastic / Transforming Growth Factor beta / Raf Kinases / Epithelial Cells Type of study: Prognostic_studies Limits: Animals Language: En Journal: Oncogene Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2006 Type: Article Affiliation country: Italy

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