Prognostic significance of bladder tumor history and tumor location in upper tract transitional cell carcinoma.
J Urol
; 176(1): 48-52, 2006 Jul.
Article
in En
| MEDLINE
| ID: mdl-16753365
ABSTRACT
PURPOSE:
We studied prognostic factors for 5-year disease specific and recurrence-free survival in patients treated for upper urinary tract transitional cell carcinoma. MATERIALS ANDMETHODS:
Since July 1987, 72 patients with a mean age of 58.9 years have undergone nephroureterectomy with bladder cuff excision. Median followup was 62.2 months (range 6 to 192). Patient age, sex, detection duration and mode, bladder tumor history, smoking habit, stone disease history, and tumor stage, grade and location were evaluated as prognostic factors.RESULTS:
Overall 5-year disease specific and recurrence-free survival rates were 74.9% and 67.8%, respectively. Univariate analysis revealed anemia, positive bladder tumor history, T stage, grade and tumor location in the upper tract as significant prognostic factors. On multivariate analysis T stage, grade and tumor location in the urothelium were the only significant variables for the 5-year disease specific and recurrence-free survival rates.CONCLUSIONS:
High tumor stage and grade, and ureteral location were significantly associated with worse disease specific and recurrence-free survival in patients with upper urinary tract transitional cell carcinoma. Our results may help define the patient groups that need adjuvant therapy and they may form a basis for further controlled studies.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ureteral Neoplasms
/
Urinary Bladder Neoplasms
/
Carcinoma, Transitional Cell
/
Kidney Neoplasms
/
Neoplasms, Multiple Primary
Type of study:
Prognostic_studies
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Urol
Year:
2006
Type:
Article
Affiliation country:
Turkey